Huntington’s Disease Research

  • See current clinical trials.

  • Join the effort to advance understanding and treatment of Huntington’s disease (HD).

Current Studies

  • Trial search ongoing, please stay tuned for future updates! 

    Have questions about Huntington’s disease clinical trials? Contact our team via email at contact@inwresearch.com or by phone at (509) 960-2818.

How to Enroll

If you’re interested in learning more about participating:

  1. Contact our team via email at contact@inwresearch.com or by phone at (509) 960-2818.

  2. A member of our team will answer your questions and explain the study in more detail.

  3. If appropriate, we can discuss next steps, including screening and eligibility requirements.

  4. You’ll receive a copy of the informed consent form and have time to review it and decide whether participation is right for you.

  5. If you choose to consent and are determined to be eligible, you may be invited to participate in the study.

Thank you for considering participation. Your involvement helps advance research and improve understanding of Huntington’s disease.

Why Your Participation Counts

By taking part in a research study, you help scientists and physicians:

  • Learn more about how Huntington’s disease starts, progresses, and affects people.

  • Test new treatments or approaches aimed at slowing, stopping, or reversing symptoms.

  • Improve the quality of life for other people currently living with HD and help those at risk for future generations.

Your involvement may also provide you with access to extra monitoring, links to HD-specialist care, and the satisfaction of contributing to a larger mission of progress and understanding.

What is Huntington’s Disease (HD)?

Huntington’s disease is a hereditary neurological disorder that gradually causes breakdown of nerve cells in the brain. The result can affect a person’s physical, cognitive, and emotional abilities.

Here are key facts:

  • HD is genetic: if a parent carries the HD gene mutation, each child has a 50% chance of inheriting it.

  • The HD gene was discovered in 1993 and involves a CAG triplet repeat expansion in the huntingtin gene on chromosome 4, which leads to a toxic protein.

  • Symptoms typically begin between ages 30-50, and disease progression may last 10–25 years.

  • Everyone who inherits the expanded gene will eventually develop HD (though the age of onset and progression vary).

  • Over time, HD affects reasoning, walking, speaking and other daily functions.

Symptoms of Huntington’s Disease.

Motor & movement symptoms

  • Involuntary movements (chorea)

  • Unsteady gait, balance problems, difficulty walking

  • Slurred speech, difficulty swallowing

  • Significant weight loss

Cognitive & behavioral symptoms

  • Mood changes: personality shifts, depression, irritability

  • Memory issues, impaired judgement, concentration problems

  • Behavioral changes: impulsivity, apathy, social withdrawal

How is HD treated today?

There is currently no cure for HD and no treatment proven to halt or reverse its progression. However, there are treatments and therapies that address symptoms and provide supportive care.

  • Medications to manage chorea (movement issues) and behavioral problems

  • Speech, physical, and occupational therapy to maintain function and quality of life

  • Genetic counseling and testing for individuals at risk

  • Research trials are underway testing disease-modifying therapies.

Who Can Join the Study?

Each research study has its own eligibility criteria. Generally, you may qualify if you are:

  • An adult diagnosed with Huntington’s disease

  • Able to commit to visits and study procedures

  • Free of certain exclusion conditions

If you’re unsure whether you qualify, please contact our team.

What Does Participation Involve?

When you agree to join our HD research study, you can expect:

  1. Screening Visit: Review of your health history, HD status, and medications.

  2. Baseline Visit: Detailed assessments including motor, cognitive, behavioural, and possibly imaging or blood/CSF biomarker collection.

  3. Follow-Up Visits: Ongoing assessments of symptoms, function, quality of life. Some visits may be virtual or home-based. Many leading HD registries invite annual monitoring.

  4. Optional Procedures: Some studies may include additional tests or treatments.

  5. Withdrawal: You have the right to withdraw at any time without affecting your regular care.

Benefits & Risks

Benefits may include:

  • Access to expert care and monitoring from HD specialists

  • Contribution to scientific advances that may one day benefit you and others.

  • Closer connection with the HD research community

Risks may include:

  • Possible side‐effects or discomfort from study procedures (if applicable)

All procedures, risks, and benefits will be clearly explained in your informed-consent document.

Frequently Asked Questions

  • No. Study-related procedures and treatments are provided at no cost. Always ask if there are any reimbursements for costs related to study participation

  • It depends on the study design; your informed consent document will explain if there is a placebo and how you will be assigned.

  • Yes. You may withdraw at any time without affecting your regular care.

  • Yes. Your regular neurologist/HD care team remains in charge of your care; the study is carried out concurrently.

  • All data is handled securely. Identifiable information is separated and protected; however, absolute confidentiality cannot be guaranteed (as required by consent forms).

Video Resources